TB-500 10mg (Thymosina Beta-4 43aa)

75,00 $

TB-500 is a synthetic 43-amino-acid peptide studied in biochemical and cellular research, particularly in experimental models focused on cytoskeletal dynamics and cellular remodeling processes. It is used in controlled research settings for the analysis of molecular pathways and phenotypes dependent on actin organization. Intended exclusively for laboratory applications.

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Independent laboratory analysis available

Report linked to the currently available batch.

Latest tested batchPC-TB10-0626E

Purity99.103%

Quantity11.92mg

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TB-500

Synthetic 43-amino-acid peptide studied in biological, biochemical, and cellular research.

Introduction

TB-500 is a synthetic peptide composed of 43 amino acids, corresponding to the sequence motif of thymosin beta-4 (Tβ4), which has been extensively studied in cytoskeleton biology. In experimental systems, peptides of the beta-thymosin family are used to investigate mechanisms of monomeric actin (G-actin) sequestration, actin filament (F-actin) dynamics, and cellular processes dependent on cytoskeletal remodeling.

Numerous experimental models have examined the role of these molecules in phenomena such as cell migration, stress fiber organization, neurite outgrowth, endothelial cell behavior, and extracellular matrix (ECM) remodeling. Preclinical literature reports studies conducted in cell cultures and animal models in which molecular, biochemical, and histological parameters related to tissue remodeling processes and cellular responses to stress are evaluated.

Biochemical Characteristics

Sequence Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Molecular formula: C212H350N56O78S
Molar mass: 4963.4408 g/mol
CAS number: 77591-33-4
PubChem CID: 16132341

The peptide structure has been characterized in biochemical studies through spectrometric analyses and high-resolution purification techniques. The complete sequence enables molecular interaction studies with cytoskeletal components in controlled experimental environments.

Experimental Research Contexts

TB-500 is used in research protocols aimed at studying cytoskeleton-dependent cellular phenotypes and evaluating signaling pathways associated with actin dynamics. Among the experimental contexts reported in the literature are:

Analysis of actin dynamics (G-actin/F-actin state, stress fiber organization)
Evaluation of cell migration and adhesion mechanisms
Studies on endothelial models and angiogenic transcriptional programs
Analysis of oxidative stress response pathways in controlled cellular systems
Preclinical neural models with morphological and molecular evaluation
Paradigmi sperimentali in modelli animali con analisi quantitative di parametri istologici e biochimici

The observed results are strongly dependent on the model used, the dosage, the experimental route of administration, and the selected analytical parameters.

Mechanistic Context

Peptides of the beta-thymosin family are traditionally described as monomeric actin-binding factors, influencing the availability of monomers for filament assembly. Since the polymerization state of actin regulates processes such as membrane protrusion, endocytosis, cytokinesis, and mechanotransduction, modulation of the G-actin/F-actin balance may alter cellular behaviors associated with cytoskeletal remodeling.

In various preclinical models, the literature reports modifications in molecular markers associated with angiogenic transcriptional programs, extracellular matrix remodeling, and cellular stress response pathways.

Summary of Preclinical Literature

The available scientific literature describes the experimental use of peptides related to thymosin beta-4 in neural, vascular, cutaneous, infectious, and cardiovascular models. Studies include histological assessments, analyses of molecular markers, measurements of inflammatory mediators, and functional parameters specific to the model used.

The interpretation of results must always be contextualized within the specific experimental design, taking into account laboratory conditions, controls, dosages, and exposure times.

Bibliographic References

Peptide Technical Data

CAS Number	901758-09-6
Sequence	Trans-3-Hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Molecular Formula	C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight	5135.89 g/mol
Purity	≥99%
Synthesis Method	Solid-phase peptide synthesis
Form	Lyophilized powder
Appearance	White lyophilized powder
Solubility	Soluble in water or 1% acetic acid
Stability & Storage	−20°C stable for 24 months; post-reconstitution storage at 4°C (4 weeks) or −20°C (6 months)
Shipping Conditions	Ambient; refrigerate upon arrival
Regulatory Status	Research use only

Storage

Storage Instructions

All Pepticore Aminos products are manufactured using a lyophilization (freeze-drying) process, which ensures product stability during shipping for up to 3–4 months.

Once reconstituted (mixed with bacteriostatic water), the peptides should be stored in the refrigerator to maintain stability. After reconstitution, they remain stable for up to 30 days.

What is Lyophilization

Lyophilization is a dehydration process, also known as cryodesiccation, in which peptides are first frozen and then exposed to low pressure. Under these conditions, the water in the vial sublimates directly from solid to gas, leaving behind a stable, white crystalline structure (lyophilized peptide).

The white powder can be stored at room temperature until reconstitution with bacteriostatic water.

Storage After Delivery

Keep peptides cool and protected from light. For use within a few days, weeks, or months, simple refrigeration at a temperature of < 4 °C (39 °F) is sufficient.

Lyophilized peptides are generally stable at room temperature for several weeks or longer; if use is expected within a few weeks or months, this storage condition is acceptable.

Long-Term Storage

For periods of several months or years, storage in a −80 °C (−112 °F) freezer is recommended as the optimal solution to preserve peptide stability.

For more information on proper storage techniques, visit:
Peptide Storage Information

Disclaimer - For Research Use Only

The products offered by Pepticore Aminos are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including – but not limited to – diagnostic, therapeutic, or recreational purposes.

By making a purchase, the customer declares that:

they are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;
they will use the product in full compliance with all applicable local, national, and European Union laws and regulations;
they will adopt appropriate safety measures during all stages of handling, storage, and disposal.

Prohibited uses:

The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;
Any direct administration or use on humans or animals is strictly prohibited;
Pepticore Aminos does not endorse or permit the use of its products for the production, testing, or development of illegal substances.

Regulatory compliance:

Pepticore Aminos does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.

Liability:

L’acquirente si assume ogni responsabilità per la manipolazione, conservazione e utilizzo del prodotto in condizioni sicure e conformi alla legge.
Pepticore Aminos non potrà essere ritenuta responsabile per danni diretti o indiretti derivanti da un uso improprio, dallo stoccaggio non corretto o da un utilizzo non autorizzato del prodotto.
Pepticore Aminos si riserva il diritto di rifiutare la vendita a qualsiasi individuo o ente sospettato di uso improprio dei propri prodotti.

In case of doubts regarding the safe and lawful use of the product, it is recommended to consult a qualified professional experienced in laboratory research.

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